Mounjaro® Medication Guide

How Mounjaro® Works

Mounjaro® (tirzepatide) is a GIP (glucose dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide) medication which can assist with weight-loss by doing the following:

  • Increasing insulin production from the pancreas. Insulin is a hormone that helps your body process glucose (blood sugar) into energy.
  • Removing excess glucose from your blood. Decreasing glucagon release after a meal.
  • Glucagon triggers your liver to store fat.
  • Slowing gastric emptying during digestion, which will make you feel less hungry.

Dosing and Storage Instructions

See instructions

How To Store Your Mounjaro® Pen

  • Store your new, unused Mounjaro® pens in the refrigerator between 36°F to 46°F.
  • Once you have used your pen, you may store it for up to 3 weeks at room temperature (between 59ºF to 86ºF) or in a refrigerator (between 36°F to 46°F).
  • You can travel with your pen as long as you use it within 3 weeks.
  • Dispose of your pens in a heavy-duty plastic storage container or an FDA-approved sharps container. The pen is not recyclable.

What If I Miss a Dose of Mounjaro®

  • If you miss a dose of Mounjaro®, please take the dose within 4 days (96 hours) of when you were originally supposed to take your scheduled dose.  
  • If it has been more than 4 days since you missed your last dose, it is recommended that you skip the dose and take the next regularly scheduled dose. Do not take 2 doses within three days of each other. Not following this guidance can lead to significant side effects.

When Should I Stop Taking Mounjaro®?

  • At the beginning of the Pine Medical program, you communicate your goal weight to your Pine Medical physician. If you achieve your goal weight or achieve a body mass index (BMI) less than 27, message your doctor. Your doctor may recommend you transition to a maitenance dose to maintain your weight loss.
  • If you believe you may have a BMI less than 30, please proactively communicate with your doctor every month regarding your current weight because it may inform the dosage for future prescriptions.

Refilling Your Prescription &
Communicating with Your Pine Medical Physician

How To Refill Your Mounjaro® Prescription

For the initial four to six months of the Pine Medical program, refilling your Mounjaro® prescription requires a monthly check-in with your Pine Medical physician. During this check-in, your physician will evaluate your weight-loss progress and determine whether it is safe to prescribe a higher dose of Mounjaro®.

The goal of the monthly check-in with your physician is to determine the proper dose of Mounjaro® which will optimize your weight-loss progress while minimizing side effects. 
Every month, we will reach out to via email during Week 3 to initiate your check-in with your physician. You can also initiate a checkin by emailing support@pinemedical.com.

When You Should Message Your Pine Medical Physician

You are able to message your physician at any time through the Pine Medical messaging portal. In addition, below are specific times you should reach out to your Pine Medical physician:

  • If you have not taken a dose of medication within the last 10 days.
  • Any time you experience severe side effects.
  • Any time you have been hospitalized with other medical conditions, or started new medications.
  • Any time your BMI is less than 27.

Additional Mounjaro® FAQs

What Are Common Side Effects of Mounjaro®?

Please message your Pine Medical physician if you are experiencing any adverse symptoms. Call 911 or go to an emergency room if you feel like you are experiencing a medical emergency.

  • Common side effects of Mounjaro® include diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, flatulence, gastroenteritis, and gastroesophageal reflux disease. 
  • Click here for the full list Mounjaro® of side effects.
  • Because nausea is most common in customers beginning treatment with Mounjaro® you will be prescribed generic Zofran (ondansetron) to help alleviate nausea, which will be available at your local pharmacy with your Mounjaro® prescription. ONLY take this medication if you have significant nausea.

Who Should Not Take Mounjaro®?

Your Pine Medical physician evaluated your health history prior to writing your initial prescription based on the medical intake form you filled out when signing up for Pine Medical. As a result, some patients may not be eligible to take Mounjaro®. If you develop any of these conditions after starting your prescription, please stop using Mounjaro® and reach out to your Pine Medical physician right away.

  • Family or personal history of medullary thyroid cancer
  • Family of personal history of multiple endocrine neoplasia Type 2 (MEN-2) syndrome
  • Currently pregnant or planning to become pregnant in the next two months
  • Currently breastfeeding
  • Retinopathies (diseases of the retina)
  • Type 1 Diabetes
  • Serious gastrointestinal disorders (Severe GERD/hiatal hernia/Crohn's diagnosis/ulcerative colitis)
  • Recent bariatric surgery (within past 6 months)
  • Pancreatitis using GLP-1s in the past or patients with chronic pancreatitis
  • Drug use disorder
  • Alcohol use disorder
  • Disordered eating
  • Gallbladder disease (does not include gallbladder removal)

Warning: Mounjaro® may cause worsening depression or suicidal thoughts, intestinal blockage, or thyroid cancer. Watch for possible symptoms, such as mood changes, abdominal pain, swelling in the neck, trouble swallowing, hoarseness, and shortness of breath. If you have any of these symptoms, tell your healthcare provider.

Additional Online Resources

Last Updated: 06/04/2023

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